https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45202 Streptococcus (GBS) and Escherichia coli (E. coli) have dominated as causes of EOS for five decades. Method: An 11-year retrospective cohort study to determine the epidemiology of EOS. Incidence rates were calculated per 1000 live births. Logistic regression with linear temporal trend and covariates for potential effect modifiers were employed. Blood culture utilisation was determined by examining the rate of babies undergoing blood culture within 72 hours of birth. Results: Among 93,584 live born babies, 65 had confirmed EOS (0.69/1000 live births); 22 term, 43 preterm. Across the 4 largest birth units, the proportion of babies having blood culture within 72 hours of birth varied from 1.9–5.1% for term and 21–35% for preterm babies. The annual change in the EOS rate was significant, OR 0.91 (95% CI, 0.84 to 0.99, p = 0.03). Group B Streptococcus was the most common cause of EOS in term neonates at 0.35/1000 live births (95% CI, 0.07–0.63) in 2006 and 0.1/1000 live births (95% CI, 0–0.2) in 2016. Escherichia coli was the most common cause in preterm babies at 3.4/1000 (95% CI, 0.11–6.76) in 2006 reducing significantly to 1.35/1000 live births (95% CI, -0.07–2.78) by 2016. Conclusions: Escherichia coli and GBS were the most common causes of EOS in preterm and term babies respectively. Rates of all cause term and preterm EOS declined significantly as did preterm sepsis due to E. coli. While rate of sepsis due to early-onset GBS declined, this did not reach significance. Given the high proportion of preterm babies undergoing blood culture, it is unlikely that any EOS events were missed.]]> Wed 26 Oct 2022 19:38:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45197 Wed 26 Oct 2022 19:37:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36488 Wed 20 May 2020 15:48:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37075 vs 21.4 (5.1) cm³; P = 0.027) despite no significant difference in body weight. Despite having a smaller TRV, there was no significant difference in eGFR between Indigenous and Non-indigenous neonates (47.8 [43.2-50.4] vs 46.2 [42.6-53.3] ml/min per 1.73 m²; P = 0.986). These infants achieve similar eGFR through hyperfiltration, which likely increases their future risk of CKD. There was no difference in microalbumin-creatinine ratio. Female Indigenous neonates, however, had significantly smaller TRV compared with Indigenous male neonates (15.9 (3.6) vs 20.6 (3.6) cm³; P = 0.006), despite no difference in eGFR, birth weight, gestational age, and weight at term corrected. Conclusion: The difference in TRV is likely to be an important risk factor for the difference in morbidity and mortality from renal disease reported between male and female Indigenous adults.]]> Wed 15 Dec 2021 16:07:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9716 Wed 11 Apr 2018 16:28:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16522 Wed 11 Apr 2018 15:22:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22796 Wed 11 Apr 2018 14:23:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32274 Thu 17 May 2018 13:51:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30870 P = 0.02; odds ratio (OR) 0.992, P = 0.03] and more time with BGL in the 7–10 mmol/l range (31 ± 34% vs. 18 ± 27%, P = 0.003; OR 1.013, P = 0.003) compared with those without neonatal hypoglycaemia. Although statistically significant, receiver operating characteristic (ROC) curve analysis showed that time spent with maternal BGLs in the range 4–7 mmol/l [area under the curve (AUC) = 0.58] or 7–10 mmol (AUC = 0.60) was not strong enough to be a useful clinical predictor of neonatal hypoglycaemia. HbA_1c in the second trimester of pregnancy (P = 0.02, OR 1.42) and percentage time spent in BGL range of 7–10 mmol/l (P = 0.001, OR 1.02) were both associated with a risk of neonatal hypoglycaemia in a logistic regression model. HbA_1c in the third trimester (P = 0.07, OR 1.28) approached, but did not reach, significance. Conclusions: These data support a BGL range of 4–7 mmol/l as an intrapartum target. Glycaemic control in the second trimester is associated with neonatal hypoglycaemia. Improvement in ante- and intrapartum glycaemic control may reduce neonatal hypoglycaemia in women with pre-existing diabetes.]]> Thu 17 Mar 2022 14:40:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13373 Sat 24 Mar 2018 10:37:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7881 Sat 24 Mar 2018 08:41:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9622 Sat 24 Mar 2018 08:35:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14390 Sat 24 Mar 2018 08:21:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30652 Mon 09 Oct 2023 14:51:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36972 Fri 21 Oct 2022 14:58:01 AEDT ]]>